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Predicting non-carcinogenic hazard quotients of heavy metals in pepper (

Marzieh Mokarram, Hamid Reza Pourghasemi, Huichun Zhang

《环境科学与工程前沿（英文）》 2020年 第14卷 第6期 doi: 10.1007/s11783-020-1331-0

摘要： Abstract • There was significant absorption of heavy metals by the pepper in contaminated soils. • The target hazard quotient (THQ) indices followed the order of Pb>Zn>>Cd » Ni. • Relationships exist between contaminated plants and electromagnetic wave. • PCA and random search can select the main spectra and predict THQ for each element. Given the tendency of heavy metals to accumulate in soil and plants, the purpose of this study was to determine the contamination levels of Cd, Ni, Pb, and Zn on peppers (leaves and fruit) grown in contaminated soils in industrial centers. For this purpose, we measured the uptake of the four heavy metals by peppers grown in the heavy metal contaminated soils throughout the four growth stages: two-leaf, growth, flowering, and fruiting, and calculated various vegetation indices to evaluate the heavy metal contamination potentials. Electromagnetic waves were also applied for analyzing the responses of the target plants to various heavy metals. Based on the relevant spectral bands identified by principal component analysis (PCA) and random search methods, a regression method was then employed to determine the most optimal spectral bands for estimating the target hazard quotient (THQ). The THQ was found to be the highest in the plants contaminated by Pb (THQ= 62) and Zn (THQ= 5.07). The results of PCA and random search indicated that the spectra at the bands of b570, b650, and b760 for Pb, b400 and b1030 for Ni, b400 and b880 for Cd, and b560, b910, and b1050 for Zn were the most optimal spectra for assessing THQ. Therefore, in future studies, instead of examining the amount of heavy metals in plants by chemical analysis in the laboratory, the responses of the plants to the electromagnetic waves in the identified bands can be readily investigated in the field based on the established correlations.

关键词： Heavy metals     Plants     Target Hazard Quotient (THQ)     Principal Component Analysis (PCA)     Random search     Electromagnetic wave    

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Features of seismic hazard in large dam projects and strong motion monitoring of large dams

Martin WIELAND,

《结构与土木工程前沿（英文）》 2010年 第4卷 第1期   页码 56-64 doi: 10.1007/s11709-010-0005-6

摘要： Earthquakes can affect large dam projects in many different ways. Usually, design engineers are focussing on ground shaking and neglect the other aspects. The May 12, 2008 Wenchuan earthquake has damaged 1803 dams and reservoirs, and 403 hydropower plants with an installed capacity of 3.3GW. Among these dams were the 132-m-high Shapai RCC arch dam and the 156-m-high Zipingpu concrete face rockfill dam. These recently completed dams are dam types which, up to now, have not experienced strong ground shaking. The widespread mass movements have caused substantial damage to dams and surface powerhouses in Sichuan. The different features of earthquake hazard are presented, i.e., ground shaking, faulting and mass movements. It is proposed to prepare project-specific safety plans for all dams, which consist of a matrix where the possible hazards and the corresponding countermeasures are listed. The earthquake behaviors of the Sefid Rud, Zipingpu and Shapai dams, which, in the past, have experienced strong ground shaking from nearby earthquakes, are discussed. Finally, the need for strong motion instrumentation of large dams is discussed. It is proposed that major dams with large damage potential, dams located in areas of high seismicity, and dams showing signs of abnormal behavior be equipped with strong motion instruments.

关键词： seismic hazard     arch dam     concrete face rockfill dam     strong motion instrumentation     reservoir-triggered seismicity     Wenchuan earthquake    

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智能城市评价指标体系(City IQ Evaluation System)： 研制过程与应用 Review

吴志强,潘云鹤,叶启明,孔翎聿

《工程（英文）》 2016年 第2卷 第2期   页码 196-211 doi: 10.1016/J.ENG.2016.02.009

摘要：

本文对全球38组现有的智能城市评价指标体系进行了系统的梳理分析后，依据体系建构、方法与指标选取等方面的特点，详细剖析了38组现有系统的二级指标和三级指标，以此归类分析后，确定智能城市评价指标体系(City IQ Evaluation System) 的通用基础。通过聚类分析，得到5个维度。依托中国工程院、德国工程院、瑞典皇家工程院、住房和城乡建设部规划管理中心、国务院发展研究中心等在内的共14个单位的275位专家，通过指标筛选、指标调整和数据标准化处理，完成了City IQ Evaluation System-1.0 基础版本的研制。并通过对指标数据源更普适、开放、动态的调整，得到了改进后的City IQ Evaluation System-2.0版本，引入IQ测评的偏差测智法得到了City IQ Evaluation System-3.0版本。研究团队基于City IQ Evaluation System对全球41个智能城市进行多轮测评。综合来看，City IQ Evaluation System 系列评价指标体系的特点包括：以智能生命体理论作支撑，以更普适、开放、动态的数据源形成指标，并以IQ 测评的思想和方法提升City IQEvaluation System 的灵敏性和准确性。

关键词： 智能城市     评价体系     开放数据     城市生命     智能度    

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Fire hazard in transportation infrastructure: Review, assessment, and mitigation strategies

Venkatesh KODUR, M. Z. NASER

《结构与土木工程前沿（英文）》 2021年 第15卷 第1期   页码 46-60 doi: 10.1007/s11709-020-0676-6

摘要： This paper reviews the fire problem in critical transportation infrastructures such as bridges and tunnels. The magnitude of the fire problem is illustrated, and the recent increase in fire problems in bridges and tunnels is highlighted. Recent research undertaken to address fire problems in transportation structures is reviewed, as well as critical factors governing the performance of those structures. Furthermore, key strategies recommended for mitigating fire hazards in bridges and tunnels are presented, and their applicability to practical situations is demonstrated through a practical case study. Furthermore, research needs and emerging trends for enhancing the “state-of-the-art” in this area are discussed.

关键词： fire hazard     bridges     tunnels     fire resistance     mitigation strategies     transportation infrastructure    

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海底碳封存环境地质灾害风险及监测技术研究

张少鹏,刘晓磊,程光伟,朱超祁,李清平,何玉发

《中国工程科学》 2023年 第25卷 第3期   页码 122-130 doi: 10.15302/J-SSCAE-2023.03.011

摘要：

海底CO2地质封存是我国实现“双碳”目标的重要组成部分，但CO2泄露具有诱发海底地质灾害的风险，威胁海洋工程的安全建设，因此开展封存区环境地质监测对海洋碳封存实施具有重要的现实意义。本文在简要介绍海底CO2地质封存示范案例的基础上，阐述了海底封存区CO2泄露的致灾机制，结合实例梳理了典型CO2控释试验中的海洋环境监测技术，重点分析了与CO2泄露相关的环境地质监测技术，包括地震调查与监测、电阻率法监测技术、重力监测技术、海床变形监测技术以及沉积物孔隙压力监测技术等，展望了我国海底碳封存及其环境地质监测的未来发展前景。研究认为，今后应侧重封存区CO2泄露致灾机制与环境地质监测技术研究，建议在研发长时序、低成本并实时监测技术的基础上，结合封存区基线调查，建立和发展系统性、智能性的多维度灾害识别模型，构建多方面、多层次、多灾种的监测预警预报体系。

关键词： 海底碳封存；环境地质；CO2泄露；灾害风险；监测技术    

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Necessity of integrated methodology for hazard mitigation of quake lakes: case study of the Wenchuan

Xudong FU, Fan LIU, Guangqian WANG, Wenjie XU, Jianxin ZHANG

《结构与土木工程前沿（英文）》 2011年 第5卷 第1期   页码 1-10 doi: 10.1007/s11709-011-0099-5

摘要： The massive 8.0-magnitude Wenchuan Earthquake triggered huge landslides, avalanches, and debris flows that blocked rivers and created 34 important quake lakes, including the Tangjiashan Quake Lake on the Tongkou River. More than half of these lakes were identified to be of moderate or high hazard levels, so activities needed to be undertaken for hazard mitigation of potential flooding. This paper presents the mitigation processes of quake lake hazards, which involve various techniques such as rapid hazard analysis, scenario-based mitigation planning, and real-time forecasting of outburst flooding for implementation actions. The shortage of hydrologic and geological data and the nature of emergency situations raise substantial challenges in the hazard mitigation of quake lakes. This paper suggests a potential approach in dealing with quake lake hazards, which integrates the automatic monitoring network, hydrologic models, and hydrodynamic models with a comprehensive indicator for hazard levels. The necessity of improving the integrated methodology is highlighted.

关键词： quake lake     hazard mitigation     dam failure     emergency     Tangjiashan    

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Hazard potential of zones of weakness in gravity dams under impact loading conditions

Herbert LINSBAUER

《结构与土木工程前沿（英文）》 2011年 第5卷 第1期   页码 90-97 doi: 10.1007/s11709-010-0008-3

摘要： Dam constructions worldwide are designed and constructed in view of the strictest safety aspects for all static and dynamic load cases. As experience shows, however, formation of cracks in the “homogeneos concrete” as well as unsatisfactory compound behavior of lift joints are not to be excluded. These zones of weakness especially on the upstream side of the dam— exposed to high water pressure (static and dynamic)— represent an increased risk of safety. The main investigation, apart from the computation of the dynamic effects on the dam as a global structure, focuses on the stability analysis of a pressure-water filled crack configuration subjected to “dynamic loading” in the form of seismic action on the dam-reservoir-system and alternatively by “impact spot-loading” within sectors of the reservoir. A fracture mechanics based analysis shows an excessive potential of damage for the afflicted structure.

关键词： dam-reservoir     earthquake     impact     cracking     fracture mechanics    

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Multi-target combinatory strategy to overcome tumor immune escape

《医学前沿（英文）》 2022年 第16卷 第2期   页码 208-215 doi: 10.1007/s11684-022-0922-5

摘要： Immune therapy has become the fourth approach after surgery, chemotherapy, and radiotherapy in cancer treatment. Many immune checkpoints were identified in the last decade since ipilimumab, which is the first immune checkpoint inhibitor to cytotoxic T-lymphocyte associated protein 4, had been approved by the US Food and Drug Administration (FDA) for the treatment of unresectable or metastatic melanoma in 2011. The use of several antibody drugs that target PD1/PD-L1 for various cancer treatments has been approved by the FDA. However, fewer people are benefitting from immune checkpoint inhibitor treatment in solid cancers. Approximately 80% of patients do not respond appropriately because of primary or acquired therapeutic resistance. Along with the characterization of more immune checkpoints, the combinatory treatment of multi-immune checkpoint inhibitors becomes a new option when monotherapy could not receive a good response. In this work, the author focuses on the combination therapy of multiple immune checkpoints (does not include targeted therapy of oncogenes or chemotherapy), introduces the current progression of multiple immune checkpoints and their related inhibitors, and discusses the advantages of combination therapy, as well as the risk of immune-related adverse events.

关键词： immune checkpoints     multi-target     immune escape     immune-related adverse events     combination therapy    

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Atypical pituitary hormone–target tissue axis

《医学前沿（英文）》 2023年 第17卷 第1期   页码 1-17 doi: 10.1007/s11684-022-0973-7

摘要： A long-held belief is that pituitary hormones bind to their cognate receptors in classical target glands to actuate their manifold functions. However, a number of studies have shown that multiple types of pituitary hormone receptors are widely expressed in non-classical target organs. Each pituitary gland-derived hormone exhibits a wide range of nonconventional biological effects in these non-classical target organs. Herein, the extra biological functions of pituitary hormones, thyroid-stimulating hormone, follicle-stimulating hormone, luteinizing hormone, adrenocorticotrophic hormone, and prolactin when they act on non-classical organs were summarized, defined by the novel concept of an “atypical pituitary hormone–target tissue axis.” This novel proposal explains the pathomechanisms of abnormal glucose and lipid metabolism, obesity, hypertension, fatty liver, and atherosclerosis while offering a more comprehensive and systematic insights into the coordinated regulation of environmental factors, genetic factors, and neuroendocrine hormones on human biological functions. The continued exploration of the physiology of the “atypical pituitary hormone–target tissue axis” could enable the identification of novel therapeutic targets for metabolic diseases.

关键词： thyroid-stimulating hormone     follicle-stimulating hormone     luteinizing hormone     adrenocorticotrophic hormone     prolactin    

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Hazard and vulnerability evaluation of water distribution system in cases of contamination intrusion

Kunlun XIN, Tao TAO, Yong WANG, Suiqing LIU

《环境科学与工程前沿（英文）》 2012年 第6卷 第6期   页码 839-848 doi: 10.1007/s11783-012-0409-8

摘要： In this paper, it proposed an index system for hazard and vulnerability evaluations of water distribution networks, based on the simulation of contamination events caused by pollutant injections at different junctions. It attempted to answer the following two questions in the case of contamination events: 1) Which are the most hazardous junctions? 2) Which are the most vulnerable junctions? With EPANET toolkit, it simulated the propagation of the contaminant, and calculated the peak concentration of the contaminant and mass delivered at different nodes. According to types of consumers, different weights were assigned to the consumer nodes for assessing the influence of the contaminant on the consumers. Using the method proposed herein, both the hazard index and vulnerability index were calculated for each node in the pipe network. The presented method was therefore applied to the water network of the city of Zhenjiang, which contains two water plants, two booster pump stations with storage tanks. In conclusion, the response time, the relationships between the peak concentration of contaminant and the total absorption are the most important factors in hazard and vulnerability evaluation of the water distribution network.

关键词： water distribution network     hazard     vulnerability     contaminant accident    

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包装型乳化炸药生产线重大危险源分析及预防措施

吴晓梦

《中国工程科学》 2014年 第16卷 第11期   页码 82-85

摘要：

乳化炸药具有良好的抗水性能、储存性能和爆轰性能，且制造工艺简单、成本低廉，已在全世界得到了广泛的推广应用。本文介绍了我国乳化炸药发展现状及生产工艺特点，结合当前国内外包装型乳化炸药的工艺技术特点，分析了乳化炸药生产线重大危险源，提出了确保乳化炸药生产本质安全的应对措施。

关键词： 乳化炸药     危险源     预防措施    

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Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

null

《医学前沿（英文）》 2016年 第10卷 第1期   页码 52-60 doi: 10.1007/s11684-016-0433-3

摘要：

Hepatocellular carcinoma (HCC) is a lethal liver malignancy worldwide. In this study, we reported that protein phosphatase magnesium-dependent 1δ (PPM1D) was highly expressed in the majority of HCC cases (approximately 59%) and significantly associated with high serum α-fetoprotein (AFP) level (P= 0.044). Kaplan-Meier and Cox regression data indicated that PPM1D overexpression was an independent predictor of HCC-specific overall survival (HR, 2.799; 95% CI, 1.346–5.818, P = 0.006). Overexpressing PPM1D promoted cell viability and invasion, whereas RNA interference-mediated knockdown of PPM1D inhibited proliferation, invasion, and migration of cultured HCC cells. In addition, PPM1D suppression by small interfering RNA decreased the tumorigenicity of HCC cells in vivo. Overall, results suggest that PPM1D is a potential prognostic marker and therapeutic target for HCC.

关键词： PPM1D     hepatocellular carcinoma     prognosis     target therapy    

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Amodified variable rate particle filter for maneuvering target tracking

Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU

《信息与电子工程前沿（英文）》 2015年 第16卷 第11期   页码 985-994 doi: 10.1631/FITEE.1500149

摘要： To address the problem of maneuvering target tracking, where the target trajectory has prolonged smooth regions and abrupt maneuvering regions, a modified variable rate particle filter (MVRPF) is proposed. First, a Cartesian-coordinate based variable rate model is presented. Compared with conventional variable rate models, the proposed model does not need any prior knowledge of target mass or external forces. Consequently, it is more convenient in practical tracking applications. Second, a maneuvering detection strategy is adopted to adaptively adjust the parameters in MVRPF, which helps allocate more state points at high maneuver regions and fewer at smooth regions. Third, in the presence of small measurement errors, the unscented particle filter, which is embedded in MVRPF, can move more particles into regions of high likelihood and hence can improve the tracking performance. Simulation results illustrate the effectiveness of the proposed method.

关键词： Maneuvering target tracking     Prolonged smooth regions     Variable rate model     Maneuver detection    

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Lightweight design of an electric bus body structure with analytical target cascading

《机械工程前沿（英文）》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0718-y

摘要： Lightweight designs of new-energy vehicles can reduce energy consumption, thereby improving driving mileage. In this study, a lightweight design of a newly developed multi-material electric bus body structure is examined in combination with analytical target cascading (ATC). By proposing an ATC-based two-level optimization strategy, the original lightweight design problem is decomposed into the system level and three subsystem levels. The system-level optimization model is related to mass minimization with all the structural modal frequency constraints, while each subsystem-level optimization model is related to the sub-structural performance objective with sub-structure mass constraints. To enhance the interaction between two-level systems, each subsystem-level objective is reformulated as a penalty-based function coordinated with the system-level objective. To guarantee the accuracy of the model-based analysis, a finite element model is validated through experimental modal test. A sequential quadratic programming algorithm is used to address the defined optimization problem for effective convergence. Compared with the initial design, the total mass is reduced by 49 kg, and the torsional stiffness is increased by 17.5%. In addition, the obtained design is also validated through strength analysis.

关键词： electric vehicle     body in white (BIW)     lightweight     analytical target cascading (ATC)    

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Dynamic Target Tracking of Unmanned Aerial Vehicles Under Unpredictable Disturbances

Yanjie Chen,Yangning Wu,Limin Lan,Hang Zhong,Zhiqiang Miao,Hui Zhang,Yaonan Wang,

《工程（英文）》 doi: 10.1016/j.eng.2023.05.017

摘要： This study proposes an image-based visual servoing (IBVS) method based on a velocity observer for an unmanned aerial vehicle (UAV) for tracking a dynamic target in Global Positioning System (GPS)-denied environments. The proposed method derives the simplified and decoupled image dynamics of underactuated UAVs using a constructed virtual camera and then considers the uncertainties caused by the unpredictable rotations and velocities of the dynamic target. A novel image depth model that extends the IBVS method to track a rotating target with arbitrary orientations is proposed. The depth model ensures image feature accuracy and image trajectory smoothness in rotating target tracking. The relative velocities of the UAV and the dynamic target are estimated using the proposed velocity observer. Thanks to the velocity observer, translational velocity measurements are not required, and the control chatter caused by noise-containing measurements is mitigated. An integral-based filter is proposed to compensate for unpredictable environmental disturbances in order to improve the anti-disturbance ability. The stability of the velocity observer and IBVS controller is analyzed using the Lyapunov method. Comparative simulations and multistage experiments are conducted to illustrate the tracking stability, anti-disturbance ability, and tracking robustness of the proposed method with a dynamic rotating target.

关键词： Unmanned aerial vehicle     Visual servoing     Velocity observer     Target tracking    

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标题 作者 时间 类型 操作

Predicting non-carcinogenic hazard quotients of heavy metals in pepper (

Marzieh Mokarram, Hamid Reza Pourghasemi, Huichun Zhang

期刊论文

Features of seismic hazard in large dam projects and strong motion monitoring of large dams

Martin WIELAND,

期刊论文

智能城市评价指标体系(City IQ Evaluation System)： 研制过程与应用

吴志强,潘云鹤,叶启明,孔翎聿

期刊论文

Fire hazard in transportation infrastructure: Review, assessment, and mitigation strategies

Venkatesh KODUR, M. Z. NASER

期刊论文

海底碳封存环境地质灾害风险及监测技术研究

张少鹏,刘晓磊,程光伟,朱超祁,李清平,何玉发

期刊论文

Necessity of integrated methodology for hazard mitigation of quake lakes: case study of the Wenchuan

Xudong FU, Fan LIU, Guangqian WANG, Wenjie XU, Jianxin ZHANG

期刊论文

Hazard potential of zones of weakness in gravity dams under impact loading conditions

Herbert LINSBAUER

期刊论文

Multi-target combinatory strategy to overcome tumor immune escape

期刊论文

Atypical pituitary hormone–target tissue axis

期刊论文

Hazard and vulnerability evaluation of water distribution system in cases of contamination intrusion

Kunlun XIN, Tao TAO, Yong WANG, Suiqing LIU

期刊论文

包装型乳化炸药生产线重大危险源分析及预防措施

吴晓梦

期刊论文

Protein phosphatase magnesium-dependent 1δ is a novel tumor marker and target in hepatocellular carcinoma

null

期刊论文

Amodified variable rate particle filter for maneuvering target tracking

Yun-fei GUO,Kong-shuai FAN,Dong-liang PENG,Ji-an LUO,Han SHENTU

期刊论文

Lightweight design of an electric bus body structure with analytical target cascading

期刊论文

Dynamic Target Tracking of Unmanned Aerial Vehicles Under Unpredictable Disturbances

Yanjie Chen,Yangning Wu,Limin Lan,Hang Zhong,Zhiqiang Miao,Hui Zhang,Yaonan Wang,

期刊论文